无溶剂无催化合成异吲哚啉类化合物Solvent-free and catalyst-free synthesis of isoindolines
钟凯凯;刘金彪;谢志强;卢俊瑞;
摘要(Abstract):
异吲哚啉类化合物是一种具有各种生理和药理作用的化合物,本文在无溶剂和无催化剂的条件下合成了一系列异吲哚啉类化合物;以邻二氯苄和苯胺为反应模型,优化了无溶剂无催化条件下的反应时间和温度;在此基础上,以不同取代的取代胺和邻二氯苄合成了15个不同取代的异吲哚啉化合物,都取得了良好的收率;该方法操作简单,实用性强,具有工业化潜力.
关键词(KeyWords): 异吲哚啉;无溶剂;无催化
基金项目(Foundation): 国家自然科学基金(21476174;21176194)
作者(Author): 钟凯凯;刘金彪;谢志强;卢俊瑞;
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DOI:
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